Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigma_AD_CAND_35	AD_Tier1	7.42e-01	8.49e-01	4.55e-01	1.91e-01
AD_Tier1	sigma_AD_CAND_35	2.08e-01	7.59e-01	8.60e-01	3.36e-01



Evaluating how well sigma_AD_CAND_35 genes are linked to AD_Tier1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_AD_CAND_35	AD_Tier1	0.58	-0.03	-0.17	-0.20	1.40
AD_Tier1	sigma_AD_CAND_35	0.44	-0.72	-0.88	-0.87	-1.32

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_AD_CAND_35	AD_Tier1	0.00	0.83	0.79	0.39	0.11
AD_Tier1	sigma_AD_CAND_35	0.00	0.29	0.03	0.02	-0.25

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigma_AD_CAND_35	35	35	
AD_Tier1	31	30	MS4A