Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
41_only_AD_CAND	GS_tier1	3.65e-01	2.37e-01	3.82e-01	9.23e-02
GS_tier1	41_only_AD_CAND	1.46e-01	6.67e-01	5.53e-01	7.78e-01



Evaluating how well 41_only_AD_CAND genes are linked to GS_tier1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
41_only_AD_CAND	GS_tier1	0.62	0.44	0.90	0.42	2.30
GS_tier1	41_only_AD_CAND	0.49	0.19	-0.26	0.29	-0.20

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
41_only_AD_CAND	GS_tier1	0.00	1.13	2.89	1.10	2.42
GS_tier1	41_only_AD_CAND	0.00	1.72	1.28	1.77	0.77

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
41_only_AD_CAND	41	41	
GS_tier1	31	30	MS4A