Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
121_onlyAD_CAND	GS_tier1	6.23e-01	7.54e-01	4.52e-01	2.63e-01
GS_tier1	121_onlyAD_CAND	3.00e-02	5.21e-01	6.83e-01	3.82e-01



Evaluating how well 121_onlyAD_CAND genes are linked to GS_tier1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
121_onlyAD_CAND	GS_tier1	0.58	-0.15	-0.25	-0.25	1.53
GS_tier1	121_onlyAD_CAND	0.47	-0.31	-1.05	-0.50	-1.29

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
121_onlyAD_CAND	GS_tier1	0.00	0.27	0.44	0.14	1.41
GS_tier1	121_onlyAD_CAND	0.01	0.19	-0.12	-0.05	-0.42

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
121_onlyAD_CAND	121	121	
GS_tier1	31	30	MS4A