Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
155_CAND_PMC_AD	GS_tier1	2.08e-01	1.35e-01	2.46e-01	1.12e-03
GS_tier1	155_CAND_PMC_AD	4.12e-02	8.74e-01	4.97e-01	9.39e-01



Evaluating how well 155_CAND_PMC_AD genes are linked to GS_tier1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
155_CAND_PMC_AD	GS_tier1	0.69	1.43	2.21	1.36	3.76
GS_tier1	155_CAND_PMC_AD	0.50	-0.04	-0.30	0.25	-0.35

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
155_CAND_PMC_AD	GS_tier1	0.00	0.20	1.55	0.31	2.84
GS_tier1	155_CAND_PMC_AD	0.01	0.77	0.28	0.90	0.03

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
155_CAND_PMC_AD	155	153	BX276092.9;IQCM
GS_tier1	31	30	MS4A