Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
49_CAND_PMC_onlyAD	GS_tier1	1.22e-01	1.65e-01	2.97e-01	6.78e-02
GS_tier1	49_CAND_PMC_onlyAD	2.86e-01	5.43e-01	3.39e-01	5.98e-01



Evaluating how well 49_CAND_PMC_onlyAD genes are linked to GS_tier1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
49_CAND_PMC_onlyAD	GS_tier1	0.65	1.60	1.79	0.93	2.98
GS_tier1	49_CAND_PMC_onlyAD	0.51	0.46	0.27	0.43	0.21

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
49_CAND_PMC_onlyAD	GS_tier1	0.00	1.87	2.80	1.10	1.75
GS_tier1	49_CAND_PMC_onlyAD	0.00	1.77	2.44	1.31	0.11

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
49_CAND_PMC_onlyAD	49	48	BX276092.9
GS_tier1	31	30	MS4A