Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
157_CAND_PMC_onlyAD	GS_tier1	8.66e-02	8.58e-02	2.46e-01	8.33e-04
GS_tier1	157_CAND_PMC_onlyAD	1.29e-01	3.35e-01	5.07e-02	4.51e-01



Evaluating how well 157_CAND_PMC_onlyAD genes are linked to GS_tier1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
157_CAND_PMC_onlyAD	GS_tier1	0.71	1.70	2.90	1.56	3.78
GS_tier1	157_CAND_PMC_onlyAD	0.53	1.59	1.33	1.46	1.45

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
157_CAND_PMC_onlyAD	GS_tier1	0.00	2.09	4.77	1.55	3.94
GS_tier1	157_CAND_PMC_onlyAD	0.01	2.37	2.19	2.22	1.82

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
157_CAND_PMC_onlyAD	157	156	BX276092.9
GS_tier1	31	30	MS4A