Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
35_AD_CAND	Ismael_GS	6.34e-01	7.11e-01	6.84e-01	2.77e-02
Ismael_GS	35_AD_CAND	2.49e-02	1.64e-01	6.52e-01	6.99e-02



Evaluating how well 35_AD_CAND genes are linked to Ismael_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
35_AD_CAND	Ismael_GS	0.65	0.01	-0.28	0.18	2.07
Ismael_GS	35_AD_CAND	0.43	-1.74	-1.22	-1.03	-1.28

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
35_AD_CAND	Ismael_GS	0.00	-0.40	-0.99	-0.15	-0.08
Ismael_GS	35_AD_CAND	0.00	-0.77	-0.65	-0.42	-0.67

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
35_AD_CAND	35	35	
Ismael_GS	14	14