Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
120_AD_CAND	Ismael_GS	8.74e-01	9.03e-01	9.46e-01	8.30e-02
Ismael_GS	120_AD_CAND	1.71e-01	7.40e-01	4.99e-04	8.30e-01



Evaluating how well 120_AD_CAND genes are linked to Ismael_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
120_AD_CAND	Ismael_GS	0.66	0.22	0.21	0.12	1.98
Ismael_GS	120_AD_CAND	0.50	0.19	0.68	0.84	-0.14

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
120_AD_CAND	Ismael_GS	0.00	0.57	0.28	0.58	3.99
Ismael_GS	120_AD_CAND	0.01	0.13	0.57	0.35	-0.00

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
120_AD_CAND	120	120	
Ismael_GS	14	14