Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
41_onlyAD_CAND	Ismael_GS	3.36e-02	1.42e-01	6.63e-02	1.07e-02
Ismael_GS	41_onlyAD_CAND	2.82e-01	1.58e-01	2.67e-02	3.00e-01



Evaluating how well 41_onlyAD_CAND genes are linked to Ismael_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
41_onlyAD_CAND	Ismael_GS	0.72	1.14	0.88	0.67	3.01
Ismael_GS	41_onlyAD_CAND	0.54	0.34	1.88	1.41	0.85

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
41_onlyAD_CAND	Ismael_GS	0.00	1.14	0.23	0.25	4.37
Ismael_GS	41_onlyAD_CAND	0.00	-0.21	1.08	1.13	0.37

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
41_onlyAD_CAND	41	41	
Ismael_GS	14	14