Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
121_onlyAD_CAND	Ismael_GS	6.06e-01	9.34e-01	8.10e-01	3.99e-02
Ismael_GS	121_onlyAD_CAND	2.06e-02	8.09e-01	1.08e-03	5.67e-01



Evaluating how well 121_onlyAD_CAND genes are linked to Ismael_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
121_onlyAD_CAND	Ismael_GS	0.66	0.08	-0.31	0.12	2.25
Ismael_GS	121_onlyAD_CAND	0.48	-0.86	-0.26	0.20	-0.72

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
121_onlyAD_CAND	Ismael_GS	0.00	0.27	-0.36	0.01	3.01
Ismael_GS	121_onlyAD_CAND	0.01	-0.24	0.02	0.17	-0.26

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
121_onlyAD_CAND	121	121	
Ismael_GS	14	14