Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
58_CAND_PMC_AD	Ismael_GS	4.59e-01	9.77e-01	7.81e-01	1.97e-01
Ismael_GS	58_CAND_PMC_AD	8.59e-03	6.91e-02	1.99e-01	1.15e-01



Evaluating how well 58_CAND_PMC_AD genes are linked to Ismael_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
58_CAND_PMC_AD	Ismael_GS	0.61	-0.60	-0.33	-0.17	1.16
Ismael_GS	58_CAND_PMC_AD	0.46	-1.40	-1.56	-1.35	-1.13

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
58_CAND_PMC_AD	Ismael_GS	0.00	-0.59	-0.62	-0.22	-0.13
Ismael_GS	58_CAND_PMC_AD	0.00	-0.50	-0.82	-0.58	-0.69

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
58_CAND_PMC_AD	58	56	BX276092.9;IQCM
Ismael_GS	14	14