Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
155_CAND_PMC_AD	Ismael_GS	7.20e-01	7.55e-01	7.90e-01	1.10e-01
Ismael_GS	155_CAND_PMC_AD	3.79e-02	6.05e-01	2.32e-03	5.23e-01



Evaluating how well 155_CAND_PMC_AD genes are linked to Ismael_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
155_CAND_PMC_AD	Ismael_GS	0.63	-0.66	-0.80	-0.27	1.80
Ismael_GS	155_CAND_PMC_AD	0.48	-1.07	-1.09	-0.54	-0.75

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
155_CAND_PMC_AD	Ismael_GS	0.00	-0.73	-1.20	-0.49	0.74
Ismael_GS	155_CAND_PMC_AD	0.01	-0.32	-0.87	-0.40	-0.70

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
155_CAND_PMC_AD	155	153	BX276092.9;IQCM
Ismael_GS	14	14