Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
155_CAND_PMC_onlyAD	Ismael_GS	7.85e-01	8.10e-01	7.20e-01	1.46e-01
Ismael_GS	155_CAND_PMC_onlyAD	2.54e-02	7.01e-01	1.79e-03	4.34e-01



Evaluating how well 155_CAND_PMC_onlyAD genes are linked to Ismael_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
155_CAND_PMC_onlyAD	Ismael_GS	0.63	-0.55	-0.65	-0.37	1.80
Ismael_GS	155_CAND_PMC_onlyAD	0.48	-1.18	-0.98	-0.62	-0.83

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
155_CAND_PMC_onlyAD	Ismael_GS	0.00	-0.81	-1.07	-0.64	-0.08
Ismael_GS	155_CAND_PMC_onlyAD	0.01	-0.39	-0.76	-0.39	-0.71

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
155_CAND_PMC_onlyAD	155	153	BX276092.9;IQCM
Ismael_GS	14	14