Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
157_CAND_PMC_onlyAD	Ismael_GS	2.97e-01	2.91e-01	2.76e-01	2.82e-01
Ismael_GS	157_CAND_PMC_onlyAD	3.45e-01	2.91e-01	5.68e-08	5.01e-01



Evaluating how well 157_CAND_PMC_onlyAD genes are linked to Ismael_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
157_CAND_PMC_onlyAD	Ismael_GS	0.55	-0.90	-2.47	-1.09	0.77
Ismael_GS	157_CAND_PMC_onlyAD	0.51	1.14	0.89	0.60	0.60

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
157_CAND_PMC_onlyAD	Ismael_GS	0.00	-0.52	-0.83	-0.63	0.09
Ismael_GS	157_CAND_PMC_onlyAD	0.01	0.45	-0.13	-0.33	-0.38

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
157_CAND_PMC_onlyAD	157	156	BX276092.9
Ismael_GS	14	14