Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
49_CAND_PMC_onlyAD	Ismeal_GS	1.15e-01	2.53e-01	1.21e-01	3.43e-01
Ismeal_GS	49_CAND_PMC_onlyAD	7.40e-01	9.37e-01	1.25e-03	6.99e-01



Evaluating how well 49_CAND_PMC_onlyAD genes are linked to Ismeal_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
49_CAND_PMC_onlyAD	Ismeal_GS	0.55	-1.14	-1.75	-0.84	0.86
Ismeal_GS	49_CAND_PMC_onlyAD	0.51	0.77	0.02	0.37	0.32

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
49_CAND_PMC_onlyAD	Ismeal_GS	0.00	-0.81	-1.18	-0.62	-0.11
Ismeal_GS	49_CAND_PMC_onlyAD	0.00	-0.04	-0.60	-0.43	-0.52

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
49_CAND_PMC_onlyAD	49	48	BX276092.9
Ismeal_GS	14	14