Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
157_CAND_PMC_onlyAD	GS_tier2	1.94e-01	6.55e-01	1.73e-01	4.47e-02
GS_tier2	157_CAND_PMC_onlyAD	8.52e-01	6.32e-01	1.02e-04	4.16e-01



Evaluating how well 157_CAND_PMC_onlyAD genes are linked to GS_tier2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
157_CAND_PMC_onlyAD	GS_tier2	0.58	-0.78	-0.15	-0.50	1.76
GS_tier2	157_CAND_PMC_onlyAD	0.50	0.19	-0.23	0.40	0.24

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
157_CAND_PMC_onlyAD	GS_tier2	0.00	-0.80	-0.69	-0.61	0.97
GS_tier2	157_CAND_PMC_onlyAD	0.01	-0.21	-0.90	-0.43	-0.50

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
157_CAND_PMC_onlyAD	157	156	BX276092.9
GS_tier2	46	43	TNSF12;IGH;TNSF13