Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
155_CAND_PMC_AD	GS_tier2	9.27e-01	6.35e-01	7.44e-01	1.55e-02
GS_tier2	155_CAND_PMC_AD	2.86e-01	6.35e-01	3.32e-03	5.28e-01



Evaluating how well 155_CAND_PMC_AD genes are linked to GS_tier2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
155_CAND_PMC_AD	GS_tier2	0.62	0.28	0.53	0.61	2.76
GS_tier2	155_CAND_PMC_AD	0.50	-0.67	-0.17	0.19	-0.26

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
155_CAND_PMC_AD	GS_tier2	0.00	-0.57	-0.56	-0.40	1.01
GS_tier2	155_CAND_PMC_AD	0.01	-0.46	-0.50	0.06	-0.46

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
155_CAND_PMC_AD	155	153	IQCM;BX276092.9
GS_tier2	46	43	IGH;TNSF13;TNSF12