Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
58_CAND_PMC_AD	GS_tier2	7.81e-01	6.99e-01	5.68e-01	2.03e-01
GS_tier2	58_CAND_PMC_AD	5.10e-01	6.51e-01	2.15e-02	3.78e-01



Evaluating how well 58_CAND_PMC_AD genes are linked to GS_tier2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
58_CAND_PMC_AD	GS_tier2	0.57	-0.28	-0.63	-0.51	1.67
GS_tier2	58_CAND_PMC_AD	0.50	0.11	0.02	0.00	-0.26

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
58_CAND_PMC_AD	GS_tier2	0.00	-0.23	-0.23	-0.50	0.94
GS_tier2	58_CAND_PMC_AD	0.00	-0.22	-0.45	-0.56	-0.69

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
58_CAND_PMC_AD	58	56	IQCM;BX276092.9
GS_tier2	46	43	TNSF13;TNSF12;IGH