Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
35_CAND_AD	tier2_GS	9.37e-01	9.57e-01	6.86e-01	2.25e-01
tier2_GS	35_CAND_AD	6.63e-01	8.53e-01	1.37e-01	8.17e-01



Evaluating how well 35_CAND_AD genes are linked to tier2_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
35_CAND_AD	tier2_GS	0.58	-0.14	0.07	-0.10	1.86
tier2_GS	35_CAND_AD	0.50	1.03	0.29	0.40	0.10

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
35_CAND_AD	tier2_GS	0.00	-0.03	0.12	-0.07	1.05
tier2_GS	35_CAND_AD	0.00	0.13	-0.56	-0.22	-0.35

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
35_CAND_AD	35	35	
tier2_GS	46	43	TNSF12;TNSF13;IGH