Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
120_CAND_AD Exclusive	tier2_GS	3.51e-01	1.47e-01	3.73e-01	2.21e-03
tier2_GS Exclusive	120_CAND_AD	2.07e-01	1.01e-01	6.90e-05	2.86e-01
120_CAND_AD Exclusive	tier2_GS Exclusive	2.99e-01	8.70e-02	3.44e-01	8.73e-04
tier2_GS Exclusive	120_CAND_AD Exclusive	2.07e-01	1.03e-01	1.07e-04	3.25e-01
120_CAND_AD Exclusive	Overlap	7.92e-01	5.35e-01	7.72e-01	3.96e-02
tier2_GS Exclusive	Overlap	1.78e-01	4.16e-01	1.98e-01	2.18e-01
Overlap	Exclusives	1.70e-01	5.33e-01	3.19e-37	9.01e-01



Evaluating how well 120_CAND_AD genes are linked to tier2_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
120_CAND_AD Exclusive	tier2_GS	0.66	1.20	2.26	1.74	3.83
tier2_GS Exclusive	120_CAND_AD	0.54	2.74	2.01	2.56	1.42
120_CAND_AD Exclusive	tier2_GS Exclusive	0.68	1.57	2.55	2.06	4.13
tier2_GS Exclusive	120_CAND_AD Exclusive	0.54	2.56	2.46	2.29	1.46
120_CAND_AD Exclusive	Overlap	0.02	-0.38	-0.60	-0.45	-1.70
tier2_GS Exclusive	Overlap	0.07	-0.01	-0.18	-0.13	-1.41
Overlap	Exclusives	0.51	-0.47	-0.72	-0.60	0.35

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
120_CAND_AD Exclusive	tier2_GS	0.01	2.55	1.80	2.06	2.54
tier2_GS Exclusive	120_CAND_AD	0.01	0.69	1.52	1.78	0.48
120_CAND_AD Exclusive	tier2_GS Exclusive	0.01	2.79	1.91	2.37	0.94
tier2_GS Exclusive	120_CAND_AD Exclusive	0.01	0.87	0.99	1.74	1.11
120_CAND_AD Exclusive	Overlap	0.00	-0.23	-0.29	-0.13	-0.25
tier2_GS Exclusive	Overlap	0.00	-0.10	-0.20	-0.15	-0.31
Overlap	Exclusives	0.01	-0.43	-0.45	-0.40	-0.01

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
120_CAND_AD Exclusive	119	119	
tier2_GS Exclusive	45	42	TNSF12;IGH;TNSF13
Overlap	1	1