Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
121_CAND_onlyAD	GS_tier2	1.15e-01	3.25e-02	1.89e-01	9.87e-05
GS_tier2	121_CAND_onlyAD	2.82e-01	4.52e-01	5.43e-04	6.80e-01



Evaluating how well 121_CAND_onlyAD genes are linked to GS_tier2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
121_CAND_onlyAD	GS_tier2	0.68	2.23	3.00	2.32	3.92
GS_tier2	121_CAND_onlyAD	0.52	1.98	1.55	1.68	0.72

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
121_CAND_onlyAD	GS_tier2	0.00	1.61	1.69	1.58	4.42
GS_tier2	121_CAND_onlyAD	0.01	1.45	1.21	1.34	0.24

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
121_CAND_onlyAD	121	121	
GS_tier2	46	43	TNSF12;TNSF13;IGH