Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
41_CAND_onlyAD	GS_tier2	4.90e-01	6.22e-01	6.99e-01	2.87e-02
GS_tier2	41_CAND_onlyAD	8.65e-01	6.57e-01	9.42e-02	9.61e-01



Evaluating how well 41_CAND_onlyAD genes are linked to GS_tier2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
41_CAND_onlyAD	GS_tier2	0.63	0.98	0.95	1.06	2.94
GS_tier2	41_CAND_onlyAD	0.53	0.63	1.35	1.25	0.46

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
41_CAND_onlyAD	GS_tier2	0.00	0.89	0.19	0.76	2.42
GS_tier2	41_CAND_onlyAD	0.00	-0.10	0.21	0.28	-0.01

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
41_CAND_onlyAD	41	41	
GS_tier2	46	43	IGH;TNSF13;TNSF12