Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
143_new_MCI_AD	GS_tier1	7.51e-01	6.79e-01	8.46e-01	1.16e-01
GS_tier1	143_new_MCI_AD	5.23e-03	4.68e-01	6.73e-01	7.55e-01



Evaluating how well 143_new_MCI_AD genes are linked to GS_tier1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
143_new_MCI_AD	GS_tier1	0.58	-0.17	-0.55	-0.18	1.56
GS_tier1	143_new_MCI_AD	0.50	-1.14	-0.89	-0.59	-0.07

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
143_new_MCI_AD	GS_tier1	0.00	-0.47	-0.40	-0.49	-0.06
GS_tier1	143_new_MCI_AD	0.01	-0.62	-0.45	-0.25	-0.09

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
143_new_MCI_AD	143	142	IQCM
GS_tier1	31	30	MS4A