Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
143_new_MCI_AD	GS_tier2	7.52e-01	5.68e-01	6.45e-01	3.25e-02
GS_tier2	143_new_MCI_AD	2.18e-01	3.36e-01	2.11e-03	4.91e-01



Evaluating how well 143_new_MCI_AD genes are linked to GS_tier2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
143_new_MCI_AD	GS_tier2	0.60	-0.47	0.29	0.14	2.09
GS_tier2	143_new_MCI_AD	0.50	-0.71	-0.66	-0.30	0.33

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
143_new_MCI_AD	GS_tier2	0.00	-0.69	-0.75	-0.09	0.33
GS_tier2	143_new_MCI_AD	0.01	-0.32	-0.60	-0.21	-0.03

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
143_new_MCI_AD	143	142	IQCM
GS_tier2	46	43	TNSF13;TNSF12;IGH