Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
143_new_AD	GS_tier1	6.91e-01	9.54e-01	9.72e-01	2.25e-01
GS_tier1	143_new_AD	4.45e-04	1.70e-01	2.39e-01	3.04e-01



Evaluating how well 143_new_AD genes are linked to GS_tier1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
143_new_AD	GS_tier1	0.58	-0.62	-0.40	-0.12	1.46
GS_tier1	143_new_AD	0.48	-0.92	-1.40	-1.23	-0.59

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
143_new_AD	GS_tier1	0.00	-0.71	-0.45	-0.32	0.50
GS_tier1	143_new_AD	0.01	-0.17	-0.66	-0.37	-0.36

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
143_new_AD	143	143	
GS_tier1	31	30	MS4A