Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
143_new_AD	GS_tier2	8.09e-02	2.32e-01	1.51e-01	1.14e-01
GS_tier2	143_new_AD	2.05e-01	3.26e-01	4.08e-03	4.98e-01



Evaluating how well 143_new_AD genes are linked to GS_tier2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
143_new_AD	GS_tier2	0.56	-1.20	-1.26	-0.90	1.45
GS_tier2	143_new_AD	0.49	-1.13	-0.97	-0.75	-0.28

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
143_new_AD	GS_tier2	0.00	-1.21	-1.29	-0.89	0.07
GS_tier2	143_new_AD	0.01	-1.24	-1.57	-1.15	-0.88

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
143_new_AD	143	143	
GS_tier2	46	43	IGH;TNSF13;TNSF12