Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
143_new_AD	GS_Ismael	8.77e-02	4.94e-02	1.29e-01	3.50e-01
GS_Ismael	143_new_AD	5.98e-03	8.44e-01	6.58e-07	7.33e-01



Evaluating how well 143_new_AD genes are linked to GS_Ismael genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
143_new_AD	GS_Ismael	0.57	-1.21	-2.29	-1.09	0.92
GS_Ismael	143_new_AD	0.51	-0.70	-0.27	0.44	0.44

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
143_new_AD	GS_Ismael	0.00	-0.93	-1.37	-0.55	0.22
GS_Ismael	143_new_AD	0.01	-0.93	-0.75	-0.37	-0.37

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
143_new_AD	143	143	
GS_Ismael	14	14