Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
131_PD_new	singleton	9.49e-01	9.94e-01	7.88e-01	5.03e-02
singleton	131_PD_new	8.85e-03	5.89e-01	8.94e-08	2.94e-01



Evaluating how well 131_PD_new genes are linked to singleton genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
131_PD_new	singleton	0.67	-0.11	0.14	-0.45	2.62
singleton	131_PD_new	0.48	-1.32	-0.93	-0.80	-0.98

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
131_PD_new	singleton	0.00	-0.15	-0.23	-0.35	1.51
singleton	131_PD_new	0.01	-0.12	-0.01	-0.22	-0.28

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
131_PD_new	131	131	
singleton	21	21