Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
131_PD_new	GS_tier1	3.72e-01	5.03e-01	6.69e-01	4.61e-02
GS_tier1	131_PD_new	7.17e-01	6.02e-02	2.21e-02	6.69e-02



Evaluating how well 131_PD_new genes are linked to GS_tier1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
131_PD_new	GS_tier1	0.61	0.51	0.82	0.17	2.20
GS_tier1	131_PD_new	0.56	3.15	3.02	2.66	2.07

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
131_PD_new	GS_tier1	0.00	1.39	2.06	0.69	0.93
GS_tier1	131_PD_new	0.01	0.82	1.45	1.54	1.00

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
131_PD_new	131	131	
GS_tier1	31	30	MS4A