Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
144_new_AD_revised	GS_tier1	2.87e-01	4.80e-01	4.12e-01	3.16e-01
GS_tier1	144_new_AD_revised	2.83e-02	8.68e-01	5.32e-01	3.12e-01



Evaluating how well 144_new_AD_revised genes are linked to GS_tier1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
144_new_AD_revised	GS_tier1	0.57	-0.44	-0.58	-0.40	1.41
GS_tier1	144_new_AD_revised	0.52	0.68	-0.06	0.38	0.62

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
144_new_AD_revised	GS_tier1	0.00	-0.10	-0.14	-0.13	0.91
GS_tier1	144_new_AD_revised	0.01	0.20	-0.31	0.22	-0.08

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
144_new_AD_revised	144	144	
GS_tier1	31	30	MS4A