Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
144_new_AD_revised	GS_tier2	6.86e-01	6.53e-01	5.09e-01	1.27e-01
GS_tier2	144_new_AD_revised	8.47e-01	6.61e-01	5.56e-04	2.89e-01



Evaluating how well 144_new_AD_revised genes are linked to GS_tier2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
144_new_AD_revised	GS_tier2	0.59	0.03	-0.18	-0.16	1.86
GS_tier2	144_new_AD_revised	0.52	0.38	0.55	0.70	0.73

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
144_new_AD_revised	GS_tier2	0.00	-0.30	-0.49	-0.40	0.48
GS_tier2	144_new_AD_revised	0.01	-0.23	-0.29	-0.15	-0.26

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
144_new_AD_revised	144	144	
GS_tier2	46	43	TNSF13;IGH;TNSF12