Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
144_new_AD_revised	GS_Ismael	9.46e-01	8.49e-01	8.53e-01	2.12e-01
GS_Ismael	144_new_AD_revised	4.78e-01	5.84e-01	5.29e-07	2.35e-01



Evaluating how well 144_new_AD_revised genes are linked to GS_Ismael genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
144_new_AD_revised	GS_Ismael	0.63	0.02	-0.37	-0.40	1.78
GS_Ismael	144_new_AD_revised	0.53	2.12	0.82	0.79	1.32

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
144_new_AD_revised	GS_Ismael	0.00	0.06	-0.06	-0.12	0.83
GS_Ismael	144_new_AD_revised	0.01	1.64	0.40	0.40	0.21

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
144_new_AD_revised	144	144	
GS_Ismael	14	14