Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
140_PD_new_revised	GS_tier1	4.77e-01	1.86e-01	7.78e-01	2.47e-02
GS_tier1	140_PD_new_revised	2.05e-01	1.16e-01	3.51e-02	5.63e-02



Evaluating how well 140_PD_new_revised genes are linked to GS_tier1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
140_PD_new_revised	GS_tier1	0.64	0.72	1.43	0.41	2.82
GS_tier1	140_PD_new_revised	0.56	2.40	2.64	1.94	2.40

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
140_PD_new_revised	GS_tier1	0.00	0.63	1.66	0.54	1.72
GS_tier1	140_PD_new_revised	0.01	1.12	0.59	0.78	1.03

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
140_PD_new_revised	140	140	
GS_tier1	31	30	MS4A