Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
140_PD_new_revised	singleton	3.96e-01	4.72e-01	8.25e-01	2.11e-02
singleton	140_PD_new_revised	1.99e-02	1.49e-01	2.35e-08	2.39e-01



Evaluating how well 140_PD_new_revised genes are linked to singleton genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
140_PD_new_revised	singleton	0.67	-1.05	0.02	-0.49	2.47
singleton	140_PD_new_revised	0.50	-1.03	-0.53	-0.60	0.02

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
140_PD_new_revised	singleton	0.00	-1.06	-0.86	-0.74	0.97
singleton	140_PD_new_revised	0.01	-0.43	-0.45	-0.59	-0.35

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
140_PD_new_revised	140	140	
singleton	21	21