Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
112_PD	singleton	5.31e-01	7.39e-01	3.21e-02	2.19e-01
singleton	112_PD	1.94e-02	3.15e-01	6.89e-05	2.57e-03



Evaluating how well 112_PD genes are linked to singleton genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
112_PD	singleton	0.59	-1.66	-0.23	-1.67	1.37
singleton	112_PD	0.42	-1.41	-1.70	-1.47	-3.07

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
112_PD	singleton	0.00	-1.46	-0.91	-1.19	-0.14
singleton	112_PD	0.00	-0.38	-1.30	-1.12	-2.36

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
112_PD	112	112	
singleton	21	21