Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
112_PD	GS_tier1	1.66e-01	1.09e-01	5.71e-01	6.98e-02
GS_tier1	112_PD	4.85e-01	8.32e-02	6.09e-02	4.53e-01



Evaluating how well 112_PD genes are linked to GS_tier1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
112_PD	GS_tier1	0.63	0.50	1.52	0.44	2.54
GS_tier1	112_PD	0.52	2.76	2.90	2.39	0.58

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
112_PD	GS_tier1	0.00	0.42	0.65	0.45	0.14
GS_tier1	112_PD	0.01	0.12	0.82	0.16	0.14

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
112_PD	112	112	
GS_tier1	31	30	MS4A