Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
37_PD	Singleton	1.03e-01	2.81e-01	2.41e-02	5.15e-02
Singleton	37_PD	6.92e-02	2.94e-01	9.98e-03	2.61e-02



Evaluating how well 37_PD genes are linked to Singleton genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
37_PD	Singleton	0.59	-1.80	-1.00	-1.39	1.52
Singleton	37_PD	0.40	-1.61	-1.32	-1.32	-2.06

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
37_PD	Singleton	0.00	-1.28	-1.17	-1.06	-0.04
Singleton	37_PD	0.00	-0.19	-1.04	-0.84	-1.15

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
37_PD	37	37	
Singleton	21	21