Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
37_PD	GS_tier1	3.91e-02	3.45e-02	1.56e-01	3.45e-02
GS_tier1	37_PD	1.66e-01	1.84e-01	1.14e-01	4.75e-01



Evaluating how well 37_PD genes are linked to GS_tier1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
37_PD	GS_tier1	0.67	1.09	2.75	0.95	2.94
GS_tier1	37_PD	0.54	2.73	2.47	1.96	0.71

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
37_PD	GS_tier1	0.00	0.95	3.49	0.77	1.30
GS_tier1	37_PD	0.00	2.21	0.62	0.02	-0.07

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
37_PD	37	37	
GS_tier1	31	30	MS4A