Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EA_APOE3_agefiltered_single_random_balancing_z35 Exclusive	TIER1_GS	8.22e-01	9.74e-01	9.97e-01	3.03e-01
TIER1_GS Exclusive	Sigma_EA_APOE3_agefiltered_single_random_balancing_z35	1.78e-01	7.81e-01	6.79e-01	9.79e-01
Sigma_EA_APOE3_agefiltered_single_random_balancing_z35 Exclusive	TIER1_GS Exclusive	6.83e-01	9.36e-01	8.90e-01	4.90e-01
TIER1_GS Exclusive	Sigma_EA_APOE3_agefiltered_single_random_balancing_z35 Exclusive	2.11e-01	8.87e-01	8.68e-01	9.87e-01
Sigma_EA_APOE3_agefiltered_single_random_balancing_z35 Exclusive	Overlap	4.95e-01	5.54e-01	6.34e-01	6.93e-01
TIER1_GS Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	9.27e-07	3.78e-06	2.23e-08	6.79e-07



Evaluating how well Sigma_EA_APOE3_agefiltered_single_random_balancing_z35 genes are linked to TIER1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_APOE3_agefiltered_single_random_balancing_z35 Exclusive	TIER1_GS	0.59	-0.34	0.07	-0.21	1.79
TIER1_GS Exclusive	Sigma_EA_APOE3_agefiltered_single_random_balancing_z35	0.50	-0.52	-0.94	-0.36	-0.19
Sigma_EA_APOE3_agefiltered_single_random_balancing_z35 Exclusive	TIER1_GS Exclusive	0.58	-0.33	0.01	-0.30	1.55
TIER1_GS Exclusive	Sigma_EA_APOE3_agefiltered_single_random_balancing_z35 Exclusive	0.49	-0.62	-0.92	-0.39	-0.30
Sigma_EA_APOE3_agefiltered_single_random_balancing_z35 Exclusive	Overlap	0.68	0.84	0.61	0.59	0.61
TIER1_GS Exclusive	Overlap	1.00	1.84	1.95	2.13	1.67
Overlap	Exclusives	0.62	2.42	3.85	2.73	3.75

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_APOE3_agefiltered_single_random_balancing_z35 Exclusive	TIER1_GS	0.00	-0.49	-0.23	-0.35	0.28
TIER1_GS Exclusive	Sigma_EA_APOE3_agefiltered_single_random_balancing_z35	0.01	1.85	0.94	1.66	0.47
Sigma_EA_APOE3_agefiltered_single_random_balancing_z35 Exclusive	TIER1_GS Exclusive	0.00	-0.40	-0.08	-0.42	-0.04
TIER1_GS Exclusive	Sigma_EA_APOE3_agefiltered_single_random_balancing_z35 Exclusive	0.00	-0.03	-0.64	-0.13	-0.07
Sigma_EA_APOE3_agefiltered_single_random_balancing_z35 Exclusive	Overlap	0.00	-0.10	-0.13	-0.11	-0.18
TIER1_GS Exclusive	Overlap	0.06	59.54	52.66	376.64	311.06
Overlap	Exclusives	0.03	16.80	47.79	17.98	23.71

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EA_APOE3_agefiltered_single_random_balancing_z35 Exclusive	78	77	AC093155.3
TIER1_GS Exclusive	30	29	MS4A
Overlap	1	1