Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) osteoCase gwas 3.02e-01 3.55e-01 3.17e-04 1.92e-02 gwas osteoCase 1.34e-02 5.17e-02 5.94e-06 6.86e-09 Evaluating how well osteoCase genes are linked to gwas genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) osteoCase gwas 0.64 0.42 1.51 1.21 2.79 gwas osteoCase 0.67 1.57 2.79 1.55 6.51 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) osteoCase gwas 0.00 -0.50 1.27 1.67 0.56 gwas osteoCase 0.01 0.91 2.46 2.03 5.93 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes osteoCase 152 151 MUC2 gwas 45 45