Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
osteoControls	gwas	1.96e-01	2.62e-01	3.83e-03	1.37e-02
gwas	osteoControls	8.40e-03	4.78e-03	6.69e-07	5.29e-09



Evaluating how well osteoControls genes are linked to gwas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
osteoControls	gwas	0.64	0.55	1.97	1.32	3.36
gwas	osteoControls	0.69	2.08	3.35	1.96	7.03

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
osteoControls	gwas	0.00	-0.39	0.83	2.67	4.13
gwas	osteoControls	0.01	2.23	2.56	2.38	7.33

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
osteoControls	111	110	MUC2
gwas	45	45