Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
osteoCase_go	gwas	3.44e-03	7.84e-03	1.42e-05	1.06e-04
gwas	osteoCase_go	8.28e-05	5.11e-04	3.62e-07	3.66e-07



Evaluating how well osteoCase_go genes are linked to gwas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
osteoCase_go	gwas	0.70	2.58	4.07	2.55	4.66
gwas	osteoCase_go	0.67	2.91	4.36	2.40	7.30

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
osteoCase_go	gwas	0.01	2.81	6.60	3.05	1.38
gwas	osteoCase_go	0.01	3.23	6.89	3.89	8.58

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
osteoCase_go	138	138	
gwas	45	45