Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
osteoCase_go Exclusive	bio	2.39e-02	5.33e-02	1.04e-06	2.79e-08
bio Exclusive	osteoCase_go	5.83e-04	7.09e-02	1.13e-03	4.00e-09
osteoCase_go Exclusive	bio Exclusive	8.23e-02	9.01e-02	1.34e-06	1.78e-07
bio Exclusive	osteoCase_go Exclusive	7.54e-04	5.55e-02	6.09e-04	8.45e-09
osteoCase_go Exclusive	Overlap	5.94e-02	1.58e-01	1.98e-02	1.39e-01
bio Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	1.92e-10	1.05e-07	1.99e-26	6.40e-18



Evaluating how well osteoCase_go genes are linked to bio genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
osteoCase_go Exclusive	bio	0.80	0.77	2.41	1.22	5.86
bio Exclusive	osteoCase_go	0.64	1.98	2.69	1.69	5.93
osteoCase_go Exclusive	bio Exclusive	0.80	0.57	1.89	1.40	5.71
bio Exclusive	osteoCase_go Exclusive	0.64	1.98	2.63	1.54	6.27
osteoCase_go Exclusive	Overlap	0.90	1.20	1.21	1.34	1.53
bio Exclusive	Overlap	1.00	1.44	2.51	2.01	1.70
Overlap	Exclusives	0.73	1.71	6.13	1.87	8.86

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
osteoCase_go Exclusive	bio	0.00	-0.33	1.54	0.51	4.52
bio Exclusive	osteoCase_go	0.01	0.54	0.88	2.47	2.51
osteoCase_go Exclusive	bio Exclusive	0.00	-0.35	1.11	0.81	4.21
bio Exclusive	osteoCase_go Exclusive	0.01	0.34	1.15	1.74	2.83
osteoCase_go Exclusive	Overlap	0.00	0.61	1.76	1.35	0.48
bio Exclusive	Overlap	0.02	27.00	36.85	87.45	36.46
Overlap	Exclusives	0.04	7.10	18.45	6.83	34.04

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
osteoCase_go Exclusive	137	137	
bio Exclusive	31	31	
Overlap	1	1