Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
osteoControls_go Exclusive	bio	7.33e-05	5.50e-05	3.43e-10	3.37e-14
bio Exclusive	osteoControls_go	1.49e-05	5.00e-02	1.41e-05	2.52e-07
osteoControls_go Exclusive	bio Exclusive	3.69e-05	9.36e-05	1.38e-09	9.56e-14
bio Exclusive	osteoControls_go Exclusive	1.22e-05	7.62e-02	9.05e-05	2.53e-07
osteoControls_go Exclusive	Overlap	3.96e-02	1.19e-01	1.98e-02	2.97e-01
bio Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	6.28e-07	2.45e-06	1.88e-05	4.12e-09



Evaluating how well osteoControls_go genes are linked to bio genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
osteoControls_go Exclusive	bio	0.85	1.97	4.69	1.99	7.03
bio Exclusive	osteoControls_go	0.62	2.65	3.34	2.22	5.78
osteoControls_go Exclusive	bio Exclusive	0.85	1.96	3.71	1.89	5.99
bio Exclusive	osteoControls_go Exclusive	0.62	2.63	3.54	1.99	5.81
osteoControls_go Exclusive	Overlap	0.90	1.93	1.77	1.88	1.23
bio Exclusive	Overlap	1.00	3.49	2.41	2.16	1.61
Overlap	Exclusives	0.65	1.22	5.02	1.26	9.08

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
osteoControls_go Exclusive	bio	0.01	0.83	4.97	2.42	11.10
bio Exclusive	osteoControls_go	0.02	5.75	12.00	9.19	14.05
osteoControls_go Exclusive	bio Exclusive	0.01	0.86	4.42	1.80	11.34
bio Exclusive	osteoControls_go Exclusive	0.01	1.72	3.84	2.53	6.14
osteoControls_go Exclusive	Overlap	0.00	2.54	0.34	2.89	0.24
bio Exclusive	Overlap	1.00	31130.09	7341.78	9058.09	1404.64
Overlap	Exclusives	0.05	10.19	34.39	8.89	47.77

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
osteoControls_go Exclusive	190	190	
bio Exclusive	31	31	
Overlap	1	1