Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
osteoControls_go Exclusive	gwas	3.19e-01	5.24e-01	1.52e-02	2.47e-02
gwas Exclusive	osteoControls_go	1.89e-01	4.21e-01	3.05e-02	2.21e-04
osteoControls_go Exclusive	gwas Exclusive	4.14e-01	8.18e-01	2.11e-02	3.36e-02
gwas Exclusive	osteoControls_go Exclusive	8.91e-02	6.37e-01	3.27e-02	2.94e-04
osteoControls_go Exclusive	Overlap	9.90e-02	1.19e-01	5.94e-02	1.58e-01
gwas Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	7.08e-05	5.20e-05	9.91e-05	2.89e-08



Evaluating how well osteoControls_go genes are linked to gwas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
osteoControls_go Exclusive	gwas	0.63	1.10	1.59	0.87	3.06
gwas Exclusive	osteoControls_go	0.58	1.32	1.32	0.59	4.09
osteoControls_go Exclusive	gwas Exclusive	0.62	0.95	1.01	0.71	3.03
gwas Exclusive	osteoControls_go Exclusive	0.58	0.93	0.92	0.67	4.28
osteoControls_go Exclusive	Overlap	0.90	1.74	1.81	1.82	1.41
gwas Exclusive	Overlap	1.00	3.65	1.95	2.14	1.74
Overlap	Exclusives	0.64	1.63	5.21	1.56	6.85

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
osteoControls_go Exclusive	gwas	0.00	0.11	1.37	0.59	0.99
gwas Exclusive	osteoControls_go	0.01	2.17	3.15	1.57	4.59
osteoControls_go Exclusive	gwas Exclusive	0.00	0.04	0.49	0.74	2.30
gwas Exclusive	osteoControls_go Exclusive	0.01	1.04	1.79	1.38	3.85
osteoControls_go Exclusive	Overlap	0.00	1.70	0.42	0.50	1.52
gwas Exclusive	Overlap	0.08	1839.56	476.33	256.63	137.95
Overlap	Exclusives	0.03	4.76	19.34	5.11	18.57

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
osteoControls_go Exclusive	190	190	
gwas Exclusive	44	44	
Overlap	1	1