Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigma_ad_122 Exclusive	tier1_31	1.16e-07	6.95e-08	1.72e-09	1.38e-10
tier1_31 Exclusive	sigma_ad_122	7.81e-02	9.35e-02	8.68e-03	3.69e-03
sigma_ad_122 Exclusive	tier1_31 Exclusive	8.91e-06	1.07e-06	4.11e-08	3.07e-08
tier1_31 Exclusive	sigma_ad_122 Exclusive	2.02e-01	2.59e-01	3.03e-02	9.98e-03
sigma_ad_122 Exclusive	Overlap	7.09e-06	1.02e-02	1.83e-06	6.04e-07
tier1_31 Exclusive	Overlap	1.83e-09	1.83e-09	1.83e-09	1.83e-09
Overlap	Exclusives	2.93e-05	1.20e-04	1.24e-16	6.46e-07



Evaluating how well sigma_ad_122 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_ad_122 Exclusive	tier1_31	0.85	3.41	7.11	3.73	7.10
tier1_31 Exclusive	sigma_ad_122	0.60	3.12	2.54	2.56	3.75
sigma_ad_122 Exclusive	tier1_31 Exclusive	0.83	4.27	6.35	3.63	5.73
tier1_31 Exclusive	sigma_ad_122 Exclusive	0.58	3.28	1.72	2.32	3.27
sigma_ad_122 Exclusive	Overlap	0.99	2.56	2.96	2.64	3.41
tier1_31 Exclusive	Overlap	1.00	2.82	3.54	3.10	4.11
Overlap	Exclusives	0.64	3.62	5.72	3.55	6.94

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_ad_122 Exclusive	tier1_31	0.02	18.80	34.90	25.38	21.85
tier1_31 Exclusive	sigma_ad_122	0.03	27.52	28.48	17.49	26.20
sigma_ad_122 Exclusive	tier1_31 Exclusive	0.01	20.34	27.83	21.89	14.30
tier1_31 Exclusive	sigma_ad_122 Exclusive	0.02	21.42	16.08	11.19	19.43
sigma_ad_122 Exclusive	Overlap	0.01	22.40	27.04	17.18	11.15
tier1_31 Exclusive	Overlap	0.10	242.38	162.28	335.99	838.19
Overlap	Exclusives	0.09	57.98	99.34	76.50	146.25

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigma_ad_122 Exclusive	118	117	RFPL2
tier1_31 Exclusive	27	26	MS4A
Overlap	4	4