Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
osteoCase_go	osteoJO	5.88e-03	1.39e-01	7.93e-08	4.35e-07
osteoJO	osteoCase_go	5.01e-02	2.98e-02	1.32e-03	3.28e-06



Evaluating how well osteoCase_go genes are linked to osteoJO genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
osteoCase_go	osteoJO	0.64	1.66	2.26	2.22	5.07
osteoJO	osteoCase_go	0.64	0.93	2.92	2.04	5.88

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
osteoCase_go	osteoJO	0.01	1.57	2.45	3.03	6.09
osteoJO	osteoCase_go	0.01	0.89	1.97	2.90	3.42

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
osteoCase_go	138	138	
osteoJO	126	126