Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EA_APOE34_balanced	tier1_31	3.75e-02	7.25e-02	2.58e-02	6.50e-03
tier1_31	Sigma_EA_APOE34_balanced	4.16e-01	2.48e-01	4.90e-02	8.07e-02



Evaluating how well Sigma_EA_APOE34_balanced genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_APOE34_balanced	tier1_31	0.68	1.83	2.23	1.37	3.20
tier1_31	Sigma_EA_APOE34_balanced	0.56	1.75	1.70	1.85	2.40

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_APOE34_balanced	tier1_31	0.00	1.97	3.69	2.11	3.04
tier1_31	Sigma_EA_APOE34_balanced	0.01	1.26	2.59	2.31	1.53

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EA_APOE34_balanced	116	115	MUC2
tier1_31	31	30	MS4A