Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EA_APOE33_old_agefilter	tier1_31	4.02e-01	1.49e-01	2.03e-01	8.43e-01
tier1_31	Sigma_EA_APOE33_old_agefilter	1.13e-02	4.98e-01	6.69e-01	6.24e-01



Evaluating how well Sigma_EA_APOE33_old_agefilter genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_APOE33_old_agefilter	tier1_31	0.52	-0.64	-2.00	-1.13	0.32
tier1_31	Sigma_EA_APOE33_old_agefilter	0.51	-2.00	-0.47	-0.90	0.46

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_APOE33_old_agefilter	tier1_31	0.00	-0.43	-0.96	-0.69	-0.21
tier1_31	Sigma_EA_APOE33_old_agefilter	0.00	-1.48	-0.45	-0.89	-0.31

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EA_APOE33_old_agefilter	73	73	
tier1_31	31	30	MS4A