Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_z3 Exclusive	tier1_31	2.53e-08	1.88e-11	2.08e-09	6.11e-13
tier1_31 Exclusive	Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_z3	1.06e-01	3.84e-01	3.55e-02	1.08e-01
Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_z3 Exclusive	tier1_31 Exclusive	6.71e-07	9.19e-10	2.17e-08	1.53e-10
tier1_31 Exclusive	Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_z3 Exclusive	1.48e-01	3.34e-01	1.25e-01	1.59e-01
Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_z3 Exclusive	Overlap	5.36e-04	6.40e-08	5.75e-05	6.04e-07
tier1_31 Exclusive	Overlap	1.83e-09	1.83e-09	1.83e-09	1.83e-09
Overlap	Exclusives	9.20e-06	2.56e-04	7.77e-20	3.40e-05



Evaluating how well Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_z3 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_z3 Exclusive	tier1_31	0.87	4.82	8.54	3.95	7.24
tier1_31 Exclusive	Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_z3	0.54	2.32	1.62	1.87	2.57
Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_z3 Exclusive	tier1_31 Exclusive	0.85	4.90	7.06	4.03	6.25
tier1_31 Exclusive	Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_z3 Exclusive	0.53	2.35	1.47	1.68	1.60
Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_z3 Exclusive	Overlap	0.99	2.36	3.44	3.07	3.93
tier1_31 Exclusive	Overlap	1.00	2.98	3.37	2.87	3.49
Overlap	Exclusives	0.59	5.84	5.13	3.51	4.92

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_z3 Exclusive	tier1_31	0.02	16.63	44.22	18.12	22.23
tier1_31 Exclusive	Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_z3	0.03	17.73	21.60	19.93	24.58
Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_z3 Exclusive	tier1_31 Exclusive	0.01	13.96	20.26	12.79	6.00
tier1_31 Exclusive	Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_z3 Exclusive	0.02	17.05	14.44	11.65	13.72
Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_z3 Exclusive	Overlap	0.03	29.22	112.05	46.30	12.54
tier1_31 Exclusive	Overlap	0.10	243.98	142.15	198.75	209.80
Overlap	Exclusives	0.07	47.68	77.68	49.30	79.23

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_z3 Exclusive	210	207	AC099811.2;RFPL2;IQCJ-SCHIP1
tier1_31 Exclusive	27	26	MS4A
Overlap	4	4